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Genetics and genomes
Genetics and genomics: what DNA research reveals about heredity, disease and evolution.
- AS109 delivers faster results than Agrobacterium
Researchers developed the Rhizobium rhizogenes strain AS109, which facilitates rapid gene expression assays in 14 plant families, including faba bean and rice, outperforming standard Agrobacterium-based methods.
- Digital PCR counts molecules without relying on a standard curve
Countable Labs partitions samples into droplets, but exceeding concentration thresholds forces the system to rely on Poisson statistics instead of direct counting.
- Borzoi-SE identifies functional hierarchy of super-enhancers across 90 human lineages
The Borzoi-SE framework predicted the functional hierarchy of super-enhancers across 90 human lineages, identifying hypersensitive site 2 as the dominant element.
- PrimeStack achieves precise integration of large DNA sequences in rice plants
The PrimeStack platform combines prime editors with serine integrase Bxb1 to achieve precise, site-specific integration of large DNA sequences in rice without DNA breaks. Targeted integration efficiency reached 45% based on junction-specific PCR analysis.
- CRISPR/Cas9 editing of the BmERR AF-2 domain
Deleting the AF-2 domain of the BmERR receptor in silkworms suppressed the expression of melanin synthesis genes. This confirmed that insect metabolic regulation requires coactivators.
- DNA analysis shows Scandinavian farmers wiped out hunter-gatherers
DNA analysis confirms that the arrival of farmers led to the complete disappearance of the local population in a short time. The study, published in Nature, is based on DNA analysis of skeletons and teeth from prehistoric people in Denmark.
- Droplet-MT integrates transcriptome and methylome at 10 000 cells per library
A new method combines transcriptomics and methylation to analyze ~21,000 cells, identifying clones in healthy blood and leukemia. The approach uses epimutations to reconstruct lineage without additional genomic data.
- Chromosome-level genome assembly of S. dorsalis reaches 266.5 Mb
Researchers presented a chromosome-level genome assembly for Scirtothrips dorsalis. The assembly contains 20,557 genes and 28.8% repetitive elements.
- CONCORD platform encodes 45 689 bits into DNA
Researchers developed the CONCORD platform combining conjugation and base editing to write data directly into living cells. The system successfully encoded 45,689 bits of information, including artifacts from NASA missions.
- Two DNA-recording systems reconstructed mouse cell family trees
The team led by Jay Shendure and Chengxiang Qiu developed DNA Typewriter to reconstruct cellular lineages. Published in Science and Cell, the studies offer high-resolution views of mammalian development.
- PepRePs reduce protein phosphorylation
Researchers developed PepRePs, a system fusing a peptide binder with a serine/threonine phosphatase to localize activity. Peptide designs were guided by protein language models, successfully reducing phosphorylation of targets like tau and Rab8A.
