RealFeedApp ACE combines conjugation and CRISPR for genome assembly
The new ACE method integrates up to 3 megabase donor DNA in two steps. This enables merging diverse genomic functions into a single synthetic genome.
- Field
- genetics and genomes
- What they did
- Researchers developed the ACE method to insert up to half a genome from a donor cell into a precisely defined position in the recipient's genome in a single step.
- Why it matters
- This enables the creation of hybrid organisms combining functions from different species, overcoming previous limitations of high cost, labor intensity, and lack of scalability in genome synthesis.
#synthetic biology#genome engineering#crispr#genomic chimera#megabase scale
