RealFeedApp CRISPR tools identified new cis-regulatory elements at the LDLR locus
Researchers used CRISPR screening and massively parallel reporter assays to identify noncoding sequences influencing LDLR expression levels. The identified elements act synergistically, complementing known sterol response elements.
- Field
- genetics and genomes
- What they did
- Researchers used a set of high-throughput functional genomic tools to analyze noncoding regions of the low-density lipoprotein receptor (LDLR) gene and identified new regulatory elements affecting its activity.
- Why it matters
- This will help better understand the mechanisms controlling low-density lipoprotein levels in the blood and associated risks of atherosclerosis and cardiovascular diseases.
#ldlr#crispr#noncoding#gene regulation#atherosclerosis
