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- CRISPR/Cas9 editing of the BmERR AF-2 domain
Deleting the AF-2 domain of the BmERR receptor in silkworms suppressed the expression of melanin synthesis genes. This confirmed that insect metabolic regulation requires coactivators.
- Field
- genetics and genomes
- What they did
- Researchers used CRISPR/Cas9 technology to delete the AF-2 region of the estrogen receptor in silkworms and observed the effects on its function.
- Why it matters
- This helps understand whether helper proteins are needed for metabolic regulation in insects, as their process differs from mammals.
#crispr#gene editing#metabolism#coactivators#silkworm
