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- Droplet-MT integrates transcriptome and methylome at 10 000 cells per library
A new method combines transcriptomics and methylation to analyze ~21,000 cells, identifying clones in healthy blood and leukemia. The approach uses epimutations to reconstruct lineage without additional genomic data.
- Field
- genetics and genomes
- What they did
- Researchers developed a method to analyze DNA methylation and gene expression together in tens of thousands of cells, allowing them to identify specific cell lineages without needing to sequence every cell's full genome.
- Why it matters
- This approach helps scientists track how blood cells develop and change over time, which is particularly useful for studying the progression of leukemia and understanding how healthy blood production recovers.
#single-cell#methylation#clonal organization#hematopoiesis#biorxiv
