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- PepRePs reduce protein phosphorylation
Researchers developed PepRePs, a system fusing a peptide binder with a serine/threonine phosphatase to localize activity. Peptide designs were guided by protein language models, successfully reducing phosphorylation of targets like tau and Rab8A.
- Field
- genetics and genomes
- What they did
- Researchers created PepRePs, a genetically encoded system that fuses a peptide binder with a phosphatase enzyme to locally control the phosphorylation of specific proteins within a cell. They used generative language models to design peptides capable of binding to target proteins like tau, Rab8A, PTEN, and STAT3, demonstrating that PepRePs effectively reduce the phosphorylation of these targets.
- Why it matters
- This could be useful for treating diseases caused by dysregulated phosphorylation, such as cancer and neurodegenerative disorders, by selectively controlling protein activity without affecting the entire protein.
#synthetic biology#generative models#phosphatases#protein engineering
