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- Two DNA-recording systems reconstructed mouse cell family trees
The team led by Jay Shendure and Chengxiang Qiu developed DNA Typewriter to reconstruct cellular lineages. Published in Science and Cell, the studies offer high-resolution views of mammalian development.
- Field
- genetics and genomes
- What they did
- Researchers developed a technology called "DNA Typewriter" that records the history of cell lineages in a mouse's DNA, enabling the tracking of mouse embryonic development from zygote to late organogenesis.
- Why it matters
- This provides a high-resolution view of how cells make fate decisions during development, which was previously difficult to track because embryos develop inside the uterus and cannot be continuously observed.
#dna typewriter#petracer#lineage tracing#mouse development#organogenesis#jay shendure#chengxiang qiu
