RealFeedApp The YAP1 protein promotes cell migration when activated in cancer cells
MIT researchers identified the YAP1 pathway, triggered by ceramides produced from a high-fat diet, as essential for colorectal cancer cells to metastasize to the liver.
- Field
- cancer research
- What they did
- MIT biologists identified a cellular pathway controlled by the protein YAP1 that is necessary for colorectal cancer metastasis, and found that a high-fat diet activates this pathway through the production of ceramides.
- Why it matters
- The researchers believe that drugs blocking ceramide production could offer a new way to prevent metastasis in patients diagnosed with colon cancer.
#colorectal cancer#metastasis#yap1#ceramides#high-fat diet#mit
