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Gene therapy
Gene therapy and gene editing: CRISPR, clinical trials and the first approved treatments.
- Shortening cell expansion cuts CAR T-therapy production to 10 days
Reducing the 10–21 day expansion phase in CAR T-cell therapy production lowers the dose required and speeds up delivery, addressing the fact that 30% of annual therapies go unused due to patient deterioration.
- Scientists found a method to regrow knee cartilage without joint replacement
Blocking an age-related protein restored cartilage in aged mice and prevented osteoarthritis after injuries, while human cartilage began producing new functional tissue.
- Researchers develop first CRISPR medicine for sickle cell disease
Five researchers from Harvard and NIH received the 2026 Warren Alpert Foundation prize for identifying BCL11A as a key regulator of the fetal-to-adult hemoglobin switch, enabling the development of Casgevy, the first CRISPR medicine for sickle cell disease and thalassemia.
- SIRT6c therapy lowers biological age in dogs
A study of 24 dogs showed reduced biological age and muscle improvements after receiving GF-1004 plasmid DNA therapy.
