RealFeedApp Senescent cancer cells stop replicating but do not die
Chemotherapy and radiotherapy induce senescence in both cancer and healthy cells, leading to higher mortality and age-related conditions in survivors. Senolytic drugs may reduce this burden.
- Field
- cancer research
- What they did
- Chemotherapy and radiotherapy cause cancer cells that are not killed to enter a state of senescence, as well as non-cancerous cells exposed to the treatment. This results in cancer survivors experiencing accelerated aging, higher mortality, and an increased risk of age-related conditions, including other cancers.
- Why it matters
- This is important because current treatments leave patients with a heavy burden of cellular senescence, and researchers are exploring senolytic drugs to selectively destroy these senescent cells and reduce these negative consequences.
#senescence#chemotherapy#senolytics#aging#cancer
