RealFeedApp Expression of mutant hTau causes synaptic disconnection
Mutant humanized tau produced similar patterns of synaptic disconnection on cortical projection neurons regardless of isoform. Mass spectrometry identified specific intracellular interactions linking tau protein structure to neural circuit dysfunction.
- Field
- the brain and neuroscience
- What they did
- Researchers created a viral tool to study how different forms of the tau protein with disease-related mutations affect synapses in the mouse cortex.
- Why it matters
- This will help understand the mechanisms linking tau protein structure to neural circuit dysfunction in neurodegenerative diseases.
#tauopathy#synaptic disconnection#intracellular interactions#humanized tau
