RealFeedApp senMAGIC pinpointed genetic determinants for PCA and ccM acids
Researchers developed small molecule biosensors combined with a genome-wide CRISPR library to pinpoint genetic determinants boosting the production of cis,cis-muconic acid in Saccharomyces cerevisiae. This approach replaced time-consuming manual strain engineering with automated high-throughput screening.
- Field
- genetics and genomes
- What they did
- Researchers engineered biosensor systems in yeast that automatically identify genes improving the production of target compounds, applying this to enhance the yield of specific acids.
- Why it matters
- This method allows for faster and more accurate identification of beneficial genetic changes compared to traditional methods, accelerating the development of high-productivity strains.
#crispr#synthetic biology#yeast#biosensor#genome-wide screen#metabolic engineering
