RealFeedApp Model shows suppressing MSH3 slows somatic instability
A Latus Bio study in Nature Communications demonstrates that inhibiting the MSH3 protein can reduce somatic DNA instability and extend lifespan by decades.
- Field
- ageing and longevity
- What they did
- Researchers developed a computational model showing that suppressing the MSH3 protein could slow down DNA errors in neurons, potentially extending life by years or decades.
- Why it matters
- This could be useful for understanding the causes of Huntington's disease, driven by DNA repeat accumulation, and developing methods to slow this natural cellular aging.
#huntington's disease#dna repair#msh3#somatic instability#latus bio#gene therapy
