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Clinics face high variability in stem cell therapy outcomes

Expanding stem cells in culture leads to senescent cells generating pro-inflammatory signals. This degrades transplant quality and diminishes therapeutic benefits.

Field
ageing and longevity
What they did
Researchers investigated how the state of stem cells, specifically the presence of senescent cells producing inflammatory signals, affects transplant quality.
Why it matters
This is important because variations in cell state can cause significant variability in therapy outcomes, potentially reducing the benefits for patients.
#stem cells#senescence#cell therapy#inflammation

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