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Top science & technology news, August 12, 2026
- SpaceXAI's Grok 4.6 Scores 61 on the Artificial Analysis Intelligence Index
LLM SpaceXAI's Grok 4.6 scores 61 on the Artificial Analysis Intelligence Index, joining the frontier with GPT-5.6 Sol and other agents.
- HN: Discovered Materials (YC P26) – AI agents to discover new materials
Discovered Materials introduces AI agents that help find new materials for the semiconductor industry. Existing GPUs have a heat problem, and Nvidia and AMD plan to increase their power.
- Introducing Unsloth Desktop 🦥
Unsloth Desktop is the first desktop app to run and train AI models locally. It allows research, export, and deployment from a single open-source app on Windows, macOS, and Linux.
- Proteomic profiling of baseline CSF and serum from HDClarity identifies signatures for Huntington disease staging and stratification
HDClarity baseline proteomic data identifies protein signatures associated with HD stage and clinical severity, allowing for better participant stratification in clinical trials.
- In vivo genome-wide CRISPR screens of human T cells in solid tumours
A model that recovers human T cells from solid tumors can identify targets to improve CAR T cell antitumor activity.
- An agent-based model of Trypanosoma brucei social motility to explore determinants of colony pattern formation
Researchers developed an agent-based model to investigate the mechanisms underlying the formation of colonies by the unicellular parasite Trypanosoma brucei, focusing on the role of various factors.
- De novo assembly and authentication of ancient DNA metagenomes with nf-core/mag
Ancient DNA provides a direct window into the evolutionary processes that have shaped living microbial species today, as well as their now extinct relatives. Advances in both sequencing methods and de novo assembly techniques have not only resulted in a flood of modern metagenomic sequencing data, but they have also allowed palaeogenomicists to retrieve vast amounts of ancient DNA from past microorganisms, including species and strains without modern reference genomes.
- AI agent hacks gym to get user a spot in pilates class
An AI agent helped Andrew Bird, from Melbourne, Australia, secure a spot in an often-overbooked Pilates class by automating tasks on the gym's website.
- Sana Biotechnology advances cell and gene therapy pipeline toward 2026 clinical trials
Sana Biotechnology is advancing its cell and gene therapy pipeline towards potential clinical trials by the end of 2026, with $160.5 million in cash reserves and a projected runway into mid-2027.
- Luminescent-reaction-enabled super-resolution imaging
A new chemistry-based framework for super-resolution imaging has been described, enabling 3D, laser-free, highly sensitive and long-term imaging of live cells without spatiotemporal resolution limitations.
- Aardvark Therapeutics Abandons Phase 3 Trials After Staff Reduction
After reducing its workforce, Aardvark Therapeutics has decided to abandon the recently terminated phase 3 trials and no longer plans to resume them as previously designed.
- Boulevard Bio Embarks on 'Beautiful Path to a Cure' with Trio of Immunology Drugs
Pharmaceutical company Boulevard Bio has embarked on a path towards a cure with three immunology drugs, supported by $65 million from Deerfield Management.
- AI coding startup Cognition reportedly already in talks to raise at $40B valuation
Cognition, makers of the AI coding agent Devin, is reportedly already talking to investors about raising another funding round with a big leap in valuation, after it raised $1 billion at a $26 billon valuation in May.
- Scientists just created female clones of male mice
Scientists have deliberately turned male mouse embryos into females for the first time.
- LLM Inference Trick Reveals AI Reasoning Traces
Researchers demonstrated that a shortcut in architecture can expose internal traces of reasoning in some frontier systems, potentially allowing recovery of sensitive information like passwords and API keys.
- Lovable Confirms New $13.3B Valuation and Raises Another $400M
Venture company Lovable has confirmed previously reported whispers about a new mega round at a $13.3 billion valuation, raising another $400 million in a Series C led by Menlo Ventures and the Scaleup Europe Fund.
- Human Brain-Wide Activation of Sleep Rhythms
During sleep, our brain undergoes highly synchronized activity orchestrated by distinct neural rhythms. Little is known about the associated brain activation during these sleep rhythms and even less about their functional implications.
- Analytical concordance of targeted next-generation sequencing and whole-genome sequencing for Mycobacterium tuberculosis drug resistance and lineage determination in West Java, Indonesia
This cross-sectional study compares resistance profiles generated by Deeplex Myc-TB tNGS assay with WGS for 116 prospectively-collected rifampicin resistant TB samples from West Java, Indonesia.
- Statistical Analysis Plan for the 'Pharyngeal Electrical Stimulation for Acute Stroke Dysphagia Trial' (PhEAST) (ISRCTN98886991)
The analysis is conducted as part of the PhEAST trial, which aims to evaluate the effectiveness of pharyngeal electrical stimulation in improving dysphagia following a stroke. The study plans to include 650 patients with severe dysphagia that does not require ventilation.
- The Social Cognition Paradox in Long-Duration Spaceflight: A VEN Fatigue Hypothesis for Duration-Dependent Emotion Recognition Decline
Long-duration spaceflight may alter social cognition, yet the underlying biological mechanisms remain unclear. Emotion Recognition Task (ERT) performance remains stable during typical 6-month International Space Station (ISS) missions but declines markedly during the 340-day NASA Twins Study, suggesting duration-dependent vulnerability. Here, we propose the Von Economo Neuron (VEN) Fatigue Hypothesis, which posits that microgravity increases demand on VEN-associated social cognitive networks, eliciting adaptive myelination during shorter missions before compensatory mechanisms fail with prolongation.
