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Top science & technology news, July 24, 2026
- First Robotic Satellite Servicer Launched
For the first time, a robotic satellite servicing spacecraft has been launched, capable of performing complex repairs in orbit.
- CRISPR enzyme kills cancer cells by shredding their DNA
Scientists have discovered a CRISPR enzyme that can be targeted at tumor-causing mutations, killing cancer cells by cutting their DNA.
- Personalized gene therapy relieves severe epilepsy in two boys
A personalized gene therapy has relieved severe epilepsy in two boys, with one of them walking independently for the first time.
- LACHESIS: Real-time Inference of Evolutionary Trajectories of Malignant Transformation from Whole-Genome Sequencing Data
We present LACHESIS, a standardized R package and Shiny app that times early and most recent common ancestors of individual tumors from whole-genome sequencing data. LACHESIS automates mutational signature-aware molecular clock modeling for trajectory reconstruction and evolution-based risk stratification.
- Serina Therapeutics completes cohort 1 dosing in Parkinson’s trial
Serina Therapeutics has completed the enrollment and dosing of Cohort 1 in its Phase 1b registration trial for advanced Parkinson's disease. All eight patients have been dosed across sites in the United States and Australia.
- [Fight Aging!] Senescent Cells Accumulate Lipid Droplets in the Aging Brain
Researchers have found that senescent cells accumulate lipid droplets in the aging brain, which is seen in various neurodegenerative conditions. This finding suggests a link between dysfunctional lipid metabolism and inflammation of microglia, an important factor in neurodegeneration.
- Single-Cell Maps Reveal Genome Reorganization in Alzheimer’s Brain Cells
This study uses single-cell multiomics and spatial transcriptomics with an AI model called Hicformer to generate a multiscale view connecting genome structure, gene regulation, and tissue organization in Alzheimer's disease.
- Artificial Intelligence-Based Clinician Decision Support System for Inherited Retinal Disease Diagnosis: A Multicenter Randomized Trial
An AI-based clinician decision support system enhances the diagnosis of inherited retinal diseases through multimodal imaging and clinical data integration, achieving 88.5% accuracy in a multicenter randomized trial.
- Efficient CRISPR/Cas9-mediated homology independent sequence replacement in vivo and non-dividing primary cells
Precise sequence replacement in non-dividing cells remains a major challenge for genome editing. Here we show that REPLACE (Rational end-joining protocol delivering a targeted sequence exchange), a homology-independent CRISPR/Cas9-based replacement strategy, enables exon- and gene-scale substitution in primary cells, in vivo tissues and post-mitotic human cardiomyocytes.
- Prospective validation of imaging and serum diagnostic biomarkers of steatohepatitis and fibrosis in MASLD: the LITMUS Imaging Study
In the LITMUS study, serum biomarkers outperformed imaging for identifying patients at risk of MASH, whereas elastography was superior for staging advanced fibrosis and cirrhosis.
- [GEN (Genetic Eng News)] Single-Cell Atlas Simultaneously Maps 3D Genome Architecture and DNA Methylation
Atlases like this one provide the labeled, cell-type-resolved training data that artificial intelligence models need to make accurate predictions. Historically, this has been a bottleneck for the field.
- Nature Aging: Lifelong dietary restriction improves health and lifespan in mice
Calubag et al. report that reduced dietary intake of the branched-chain amino acid valine is sufficient to improve healthspan in both male and female mice, as well as to extend lifespan in male mice.
- Glycocalyx-Directed Enzymatic Hydrogels Unlock Fibroblast Regeneration to Promote Diabetic Wound Healing
The new study identifies pathological glycocalyx thickening in diabetic dermal fibroblasts (DDFs) as a driver of elevated caspase 3, 8, and 9 expression and heightened apoptosis - deficits that stall wound repair. Cleavage of sialic acid residues by neuraminidase (NMase) reverses this dysfunction, restoring fibroblast migration, proliferation, and contractility.
- The Fabled Flatbreads of Uzbekistan (2015)
This article from HackerNews front discusses the legendary flatbreads of Uzbekistan, which feature intricate patterns that aid in baking in a clay oven and are considered one of the world's oldest staples.
- Brain scans hint at new way to slow Alzheimer’s
New data suggest LM11A-31 may help preserve the brain's communication networks, offering another promising path in Alzheimer’s research.
- IEEE Spectrum: K.J. Ray Liu Honored for His Leadership as President of IEEE in 2022
K.J. Ray Liu was honored as the president of IEEE in 2022 for his leadership and contributions to the field of electrical engineering.
- MIT Technology Review: Organ transplant breakthrough and homegrown Chinese chips
A landmark achievement in organ transplantation has been made with supercooled kidneys transplanted into pigs. Additionally, there are developments in homegrown Chinese chip technology.
- Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork
This study investigates transcriptomic differences between high flow (HF) and low flow (LF) regions in mouse and human trabecular meshwork tissue, aiming to better understand intraocular pressure regulation.
- Ars Technica: Judge Rejects Trump Administration's Demand for New York Times Reporters' Phone Records
Federal judge Arun Subramanian rejected the Department of Justice's demand for phone records and grand jury testimony from New York Times reporters who wrote about security concerns related to Air Force One jet donated by Qatar to President Trump.
- The quest to keep organs alive outside the body
This week, I covered a fascinating effort to preserve organs outside the body. There’s a huge shortage of donor organs, and one of the main reasons is time—they survive only a matter of hours outside the body, even when they’re kept on ice.
