RealFeedApp Risk for 188 relatives was refined
Parent-of-Origin-Aware genomic analysis (POAga) clarified risk estimates for 188 relatives. Only 9 out of 13 contacted probands provided blood samples to determine variant segregation.
- Field
- medicine and diagnostics
- What they did
- Researchers evaluated the impact of a new analysis method called Parent-of-Origin-Aware genomic analysis (POAga) on identifying hereditary genetic variants in 100 patients with pancreatic cancer. The method determines whether a genetic variant came from the mother or the father, clarifying which side of the family is at risk.
- Why it matters
- If applied at the time of diagnosis, this method could have immediately refined risk estimates for at least 188 relatives, helping them decide whether to undergo genetic testing.
#cascade testing#pancreatic cancer#parent-of-origin analysis#germline variants#poaga
