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Impaired removal of senescence cells due to aging

The study found that age-related decline in chaperone-mediated autophagy impairs the clearance of senescence cells. The article also reviews differences identified in gut microbiome composition between young, old, and older adults.

Field
ageing and longevity
What they did
Researchers described how the decline in chaperone-mediated autophagy over time hinders the removal of senescent cells, which cause aging.
Why it matters
This knowledge helps understand the biological causes of aging and find ways to restore cellular cleaning functions to extend life.
#senescence#chaperone-mediated autophagy#aging#gut microbiome#cellular clearance

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