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- Senescent cells accumulate in later life
While the immune system clears senescent cells efficiently in youth, this clearance mechanism falters in later life, allowing these cells to accumulate.
- Field
- ageing and longevity
- What they did
- Researchers described how aging leads to the accumulation of cells that have stopped dividing but continue releasing harmful signals. In youth, the immune system efficiently removes these cells, but this mechanism fails in later life.
- Why it matters
- This helps explain why more damaged cells accumulate with age, which can accelerate aging and increase the risk of diseases.
#senescence#chaperone-mediated autophagy#immune system#aging
