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Top science & technology news, October 1, 2026
- New molecule ISM1354 shows 45-fold safety margin in monkeys
Insilico Medicine nominated ISM1354, an AI-generated small molecule targeting the glucose-dependent insulinotropic polypeptide receptor, for safety trials. Preclinical data show 18-fold greater plasma exposure than a clinical benchmark and minimal hepatocyte cytotoxicity.
- New complex waves reveal brain's inner workings
New research reveals that collective electrical activity of neurons forms complex waves helping the brain instantly assess the body's energetic state.
- AI tool reconstructs images from brain scans
A new AI tool predicts what a person is looking at by analyzing brain scans and recreates the image with high precision. Researchers from the Weizmann Institute hope it will help paralyzed individuals communicate and decode dreams.
- FDA has made fighting aging a priority
Senior FDA officials outlined the approval process for anti-aging therapies at ARDD 2026, confirming that longevity is a priority for the agency.
- Model analyzes MRI data regardless of atlas used
The AREION model unifies functional MRI data from diverse brain atlases without retraining by mapping regions into a shared space and processing connectivity as token sequences.
- ROVER-dMRI improves signal-to-noise ratio by 13x
The ROVER-dMRI method achieves isotropic resolution of 0.78 mm in humans and 0.6 mm in monkeys using rotating-view acquisitions and implicit neural representations.
- Unsloth Desktop speeds up Laya decisions 4x
The new desktop interface introduces a command palette and allows sharing GGUF model run settings. Laya decision speed increased to 4.1x, while NVFP4 LoRA checkpoints reduce peak memory usage by 45%.
- fUSI scans the brain without a magnet
Functional ultrasound imaging (fUSI) captures rapid brain activity movies with 1000x higher resolution than MRI, eliminating the need for magnets while integrating naturally with low-intensity focused ultrasound therapy.
- HG002 v5.0q adds 200 Mbp of callable sequence
The new HG002 v5.0q benchmark, based on a fully phased assembly, adds 200 Mbp of sequence and increases variant detection by 18% for small variants and 3-fold for structural variants.
- Alex Federation seeks drugs for undruggable targets
Alex Federation developed a model that predicts molecular binding to proteins in their native cellular context without requiring their 3D structure.
- Control policy trained on 9.4 hours of data
The TERRA pipeline recovers support geometry using terrain priors and contact constraints to train a single muscle-actuated control policy.
- Engineered CAR T cells overcome activation toxicity limitations
Researchers engineered a fully human suicide switch based on Caspase-Activated DNase (CAD) and its chaperone ICAD, fused to a lenalidomide-inducible system. The system controls hyperactivation and ensures complete cell depletion while avoiding fitness costs.
- 40 000 developers chose agent platforms
AI startup Photon held a funeral for mobile apps and secured $4.5 million in seed funding to build agents for iMessage and WhatsApp. The company has onboarded over 40,000 developers and grew its revenue 10x in four months.
- Flow Engineering raises $50 million in Series B round
Flow Engineering raised a $50 million Series B round from investors including Valar Equity Partners, Atreides Management, and Sequoia Capital to develop AI agents for hardware design.
- Method to evaluate magic energy for N-qubit states
The authors prove that the Robustness of Magic for N-qubit X-states is at most the square root of three and introduce an efficient method to lower-bound RoM for arbitrary many-body states.
- Quantum operators reduce CX operations by 28 percent
Researchers developed an exact diagonal completion method for QAOA that reduces the number of controlled-NOT operations by 28 percent on average across 60 test cases.
- G574E mutation in EGL-2 channel suppresses sleep
The G574E mutation in EGL-2 enhances potassium channel activity by inhibiting ALA neurons, a process that requires both an intact potassium selectivity filter and ligand-occupied CNBHD domains.
- Synthetic biology creates safe NDV vaccine
A computationally guided attenuation strategy introduced synonymous substitutions in the first ~900 nucleotides of the NDV fusion protein, allowing safe in-ovo vaccination of embryos while preserving active immunity.
- Google Gemini 4 Argon saved 300 TB of memory
The Gemini 4 Argon model leverages fleet-wide telemetry to optimize memory, migrating thousands of code lines to Rust. It achieved a 77.9 percent score on the DeepSWE v1.1 benchmark.
- Pennsylvania health department reports 943 measles cases
A fifth unvaccinated person has died of measles in Pennsylvania, while the CDC continues to undercount total deaths. Lancaster County has reported 381 cases and three deaths, including two infants.
