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Top science & technology news, September 28, 2026
- Starship rocket reaches orbit on Monday morning
SpaceX's Starship rocket successfully reached orbit on September 28. Standing 124 meters tall, both its stages are designed for full reusability.
- Vespper speeds up Word editing 3x faster
Vespper released a tool enabling AI agents to edit Word documents three times faster and twice as cheaply than the closest alternative.
- Social isolation acts as a primer for neurodegeneration
The study found that isolating young flies alone acts as a primer, leading to accelerated accumulation of abnormal TDP-43 aggregates later in life.
- Instinct raises $1 billion, valued at $10 billion
Instinct confirmed a Series C round with investors including Sequoia Capital and Benchmark Capital, valuing the company at $10 billion. The invite-only service launched in August 2026 and doubled its valuation in just one month.
- Resolution Therapeutics has dosed the final patient in the EMERALD trial
Resolution Therapeutics has completed the dosing phase of the EMERALD trial, administering the engineered macrophage therapy RTX001 to all patients with end-stage liver disease.
- Most glial types gradually change their transcriptome as they mature
The study reveals that neuropil glia, appearing as a single class in larvae, divides into ensheathing and astrocyte-like types during pupation.
- 1 of 10 patients improved without additional therapy
In the ALTITUDE study, 60% of participants receiving dose level 3 (1.0×10^12 GC/eye) showed greater than two-step improvement on the Diabetic Retinopathy Severity Scale for three years without additional treatment. No intraocular inflammation was observed over the three-year period.
- The @fUS platform combines 128 channels with 10 Hz sampling
The @fUS platform integrates purpose-built hardware with AI agents for hands-free experimental control. It enables functional brain imaging through the intact skull in mice with approximately 100-micron spatial resolution and 10-Hz temporal sampling.
- Model identifies deviations in 10 349 cases
Researchers developed a generative model using data from 10,349 healthy subjects to detect anomalies in primary sulcal patterns. The algorithm combines generative reconstruction error with a diffusion-based discriminator to assess the severity of neurological deviations.
- 1.6-billion-parameter generative foundation model RNASeek
Researchers introduced RNASeek, a 1.6-billion-parameter generative model trained on cross-phyla transcriptomic data. It leverages natural-language tokens to predict ribozyme self-cleavage activity and viral mRNA stability.
- SpaHCC integrates data for analysis
The proposed SpaHCC method addresses cell-to-spot mapping uncertainty by combining molecular features, spatial neighborhoods, and prior biological knowledge.
- Researchers visualize enzymes returning to vulnerable DNA regions
Researchers at Kanazawa University visualized nucleases repeatedly returning to weak spots on DNA molecules before breaking them apart. This high-speed imaging revealed how DNA's local shape and organization influence its vulnerability to enzymatic breakdown.
- Variational quantum circuits bypass entropy issues
Using unit-quaternions instead of SU(2) matrices reduces encrypted weight update costs to a single multiplication level, completely eliminating the need for bootstrapping. This is achieved because group element addition is exactly bilinear in this system.
- Working coding agents appeared in Claude Opus 4.5 and GPT-5.1
The author reviewed 2026 trends, noting that Claude Opus 4.5 and GPT-5.1 released in November 2025 marked a breakthrough in their coding agents functionality.
- Interactive tutorial explains LLM mechanics
The author dissects open-weight models to show how tokens, context windows, and temperature drive responses, using Gemma3:4b as a case study recorded in raw next-token mode.
- Vishal Sankhala left Ethos and founded Outmarket in late 2023
Founder Vishal Sankhala launched a startup using AI to automate paperwork for insurance agencies. The company secured funding just months after its previous funding round.
- 105 alternative 5' splice-site events define ReNU syndrome molecular hallmark
Researchers developed a minimal biomarker for ReNU syndrome using a signature of 105 alternative splicing events, which included only 6 sites in the final version. This method accurately distinguished individuals with the n.64_65insT mutation from healthy controls without false positives.
- New qLDPC code with non-Abelian D4 topological order
The paper unifies Sipser-Spielman codes and Dijkgraaf-Witten twisted gauge theories using sheaf cohomology to describe non-Abelian qLDPC codes with D4 topological order.
- BOB-seq v0.1 eliminates library fragmentation step
The new BOB-seq technology enables sequencing of internal RNA positions without library fragmentation, achieving sample mixing accuracy above 99%.
- A camera system could help clinicians assess patient gait
Systems performing well in controlled lab settings often fail when deployed in homes, hospitals, or city streets. A key challenge is ensuring robots work reliably in messy, unpredictable, or low-visibility conditions.
