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Top science & technology news, August 19, 2026
- Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma
Moderna and Merck announced positive Phase 3 results for individualized mRNA therapy intismeran autogene in combination with KEYTRUDA for resected stage IIB-IV melanoma, meeting primary and secondary endpoints.
- Psychedelics align brain activity with context
Psilocybin reorganizes brain activity into structured, context-aligned patterns that integrate internal and external processing, explaining how the psychedelic state leads to psychological change.
- How do people live beyond 110? Abundance of cancer-killing cells might be key
Research suggests that longevity beyond 110 may be linked to a high abundance of cells capable of killing cancer cells.
- FDA clears AI software to help analyze brain scans for cognitive decline
FDA cleared AI software NeuroQuant PET for analyzing brain scans. The tool helps doctors evaluate patient pathologies and interpret PET scans for cognitive impairment.
- Unsloth Dynamic 3.0 GGUFs
Unsloth released Dynamic 3.0 GGUFs with improved accuracy while maintaining model size.
- Differential upregulation of metabolic demands and functional integration of the default mode network during stress
Psychosocial stress activates coordinated physiological and neural responses, but maladaptive stress and reduced resilience are linked to psychiatric and neurodegenerative disorders. The study shows stress affects metabolism and functional integration of the default mode network.
- AI tool lets researchers 'vibe code' in the quantum realm
An autonomous AI agent can write and execute quantum computing code, but sometimes requires human input.
- Cognitive exertion reshapes resting-state EEG markers across the adult lifespan
rsEEG markers like iAPF and alpha power shift with cognitive exertion, indicating dynamic brain aging patterns.
- AI isn’t close to curing cancer. This startup says it knows what it will take
Biotech startup Vivodyne claims the AI drug-discovery industry has a data problem and has built a machine to fix it. HIVE, modular robotic labs, can grow 20 types of human tissue and generate causal biological data missing from current AI models.
- United Therapeutics completes enrollment in progressive pulmonary fibrosis study
United Therapeutics completed enrollment of 754 patients in a phase 3 trial of nebulized Tyvaso for progressive pulmonary fibrosis, with the primary endpoint measuring lung capacity changes over 52 weeks.
- The Feedback Cap: Lehman's laws in the age of AI agents
The Feedback Cap limits what AI agents can learn, challenging traditional software development assumptions about who creates, maintains, and uses software.
- Tolerance Bio jumps into phase 2 with $260M deal for thymus-targeting fusion protein
Tolerance Bio has secured rights to a thymus-targeting fusion protein for up to $260 million to advance into phase 2 trials.
- A ‘renaissance for biomedicine’: human brain organoids model development for 5 years
Scientists have developed brain organoids that can model brain development over five years.
- CK2α restriction of STING accumulation underlies systemic aging
Research shows that restricting CK2α reduces STING accumulation, which is linked to systemic aging.
- Home batteries are suddenly cheap and everywhere. Here’s why.
Competition in the home battery market is intensifying, with startups challenging established players by offering lower prices.
- GxP-Agent: Process-DAG Topology for Reliable Clinical Trial Programming with LLM Agents
GxP-Agent encodes regulatory process ordering as a directed acyclic graph (DAG), decomposing monolithic dataset generation into 15 domain-specific nodes executed by worker agents.
- Heme acts as a metabolic brake on erebosis in the Drosophila gut
Research shows that heme acts as a metabolic brake on erebosis — a novel form of cell death in the Dros. gut. This could have implications for understanding tissue homeostasis regulation.
- Prospective evaluation of a large language model clinical decision support system in the emergency department
A pilot study of an LLM-based clinical decision support system in an emergency department showed safe integration but declining adoption over four weeks.
- mRNA Cancer Vaccine Succeeded in Phase 3 Melanoma Trial, Moderna and Merck Say
Moderna and Merck announced their mRNA-based vaccine, tailored to target a patient's unique cancer mutations, was effective in a Phase 3 trial for melanoma.
- BYOKs for an LLM with a Brain
A.L.I.C.E. Brain Core provides memory and reasoning for apps via HTTP API.
